molecular mechanisms of methimazole cytotoxicity in isolated rat hepatocytes

Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes.

Methimazole is an antithyroid drug widely used in the treatment of hyperthyroidism. Administration of this drug, often in a chronic manner, is associated with several adverse drug reactions in humans, including life-threatening hepatotoxicity. This study attempted to investigate the cytotoxic mechanism(s) of methimazole toward isolated rat hepatocytes. In addition, the role of proposed methimaz...

Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes

     It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...

Ameliorative Effects of Taurine Against Methimazole-Induced Cytotoxicity in Isolated Rat Hepatocytes

Methimazole is used as an antithyroid drug to control the symptoms of hyperthyroidism and maintain patients in a euthyroid state. Administration of this drug is associated with agranulocytosis and hepatotoxicity, which are the two most significant adverse effects. The present investigation was conducted to study the protective role of taurine against cytotoxicity induced by methimazole and its ...

metabolism and cytotoxic mechanisms of nitroglycerin in isolated rat hepatocytes

it has been proposed that organic nitrates such as glyceryl trinitrate (gtn), used in the treatment of cardiovascular diseases, act by producing nitric oxide (no). however, the biochemical pathway for no formation from gtn is not well understood. in the present study, we showed that nitrate formation from gtn, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione was de...

Metabolism and cytotoxicity of hydrazine in isolated rat hepatocytes.

Chloroacetonitrile-Induced Cytotoxicity and Oxidative Stress in Isolated Rat Hepatocytes

Chloroacetonitrile (CAN) is a disinfectant by-product of drinking water chlorination. The present work was designed to investigate the cytotoxic effects as well as the oxidative stress induced by CAN in isolated rat hepatocytes. Hepatocytes were exposed to different concentrations of CAN (5–40 μM) in a time-course experiment for up to 2 h. CAN exposure induced a significant decrease in cell via...